4-((7-METHOXY-2,3-DIHYDRO-1,4-BENZOTHIAZEPIN-4(5H)-YL)METHYL)BENZOIC ACID, HEMIFUMARATE
Also: ARM-210 HEMIFUMARATE, BENZOIC ACID, 4-((2,3-DIHYDRO-7-METHOXY-1,4-BENZOTHIAZEPIN-4(5H)-YL)METHYL)-, (2E)-2-BUTENEDIOATE (2:1), Surlorian he…
Open FDA's page for this record- Substance class
- chemical
- Definition type
- PRIMARY
- Definition level
- COMPLETE
- Uuid
- 88260f82-f923-447f-8b21-a0f1c8e8eecb
- Version
- 10
- UNII
- ZHR6WM1ADJ
- Codes
- Uuid
- f914e723-6067-4bab-b9c0-247ad73b4546
- Code
- 1467606-11-6
- Type
- PRIMARY
- Url
- https://commonchemistry.cas.org/detail?cas_rn=1467606-11-6
- Code system
- CAS
- References
- 7ac104c6-6ca3-4a5c-9a95-6f7e157a3b3f, 88bbdd07-e102-44cd-a373-3548baaef518
- Uuid
- 6b86601a-862a-cdfb-ded3-a7e12b55cfa3
- Code
- 501515
- Comments
- ORPHAN DRUG|Designated|Treatment of patients with Duchenne Muscular Dystrophy.
- Type
- PRIMARY
- Url
- https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=501515
- Code system
- FDA ORPHAN DRUG
- Uuid
- 04280bd5-e1f0-41b5-9a70-696a17eb1e3a
- Code
- 92135933
- Type
- PRIMARY
- Url
- https://pubchem.ncbi.nlm.nih.gov/compound/92135933
- Code system
- PUBCHEM
- References
- 84180883-73b3-dbc2-78dc-9016f31541fc
- Uuid
- 8a25a4fc-a038-b0c4-eed5-720a86146463
- Code
- 558016
- Comments
- ORPHAN DRUG|Designated|Treatment of Ryanodine receptor type 1-related myopathies
- Type
- PRIMARY
- Url
- https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=558016
- Code system
- FDA ORPHAN DRUG
- References
- 57e9f12a-d403-6c8f-ab41-533ede864ab9
- Uuid
- 5ab8f85f-ffa5-ac58-9fb1-945543896a36
- Code
- 736220
- Comments
- ORPHAN DRUG|Designated|Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia
- Type
- PRIMARY
- Url
- https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=736220
- Code system
- FDA ORPHAN DRUG
- References
- 57e9f12a-d403-6c8f-ab41-533ede864ab9
- Uuid
- fe11b18c-9c2c-4a3e-b07c-8e58617a8ae2
- Code
- ZHR6WM1ADJ
- Type
- PRIMARY
- Code system
- FDA UNII
- Relationships
- Uuid
- 761bc91b-3a09-454e-a766-e7429465729a
- Type
- ACTIVE MOIETY
- Amount
- Uuid
- 3a300647-478d-48b5-b95c-9da12aa1b03c
- Related substance
- Uuid
- 34e906c4-002d-4390-ae2c-075bda4992ca
- Refuuid
- 4424fbd1-bb6e-447f-a0ae-7def6119cd9e
- Name
- Surlorian
- UNII
- 1033GN605L
- Linking ID
- 1033GN605L
- Ref pname
- Surlorian
- Substance class
- reference
- Uuid
- ef0acaa4-83a7-4738-b708-1cb3185a6089
- Type
- PARENT->SALT/SOLVATE
- Amount
- Uuid
- e9075578-c63a-45c4-8504-cd182e959251
- Related substance
- Uuid
- aad97402-eb1d-4ea4-900b-156db77b6aee
- Refuuid
- 4424fbd1-bb6e-447f-a0ae-7def6119cd9e
- Name
- Surlorian
- UNII
- 1033GN605L
- Linking ID
- 1033GN605L
- Ref pname
- Surlorian
- Substance class
- reference
- Names
- Uuid
- e59e9ec2-0d5e-4fb2-8197-3cb200357f9d
- Name
- 4-((7-METHOXY-2,3-DIHYDRO-1,4-BENZOTHIAZEPIN-4(5H)-YL)METHYL)BENZOIC ACID, HEMIFUMARATE
- StdName
- 4-((7-METHOXY-2,3-DIHYDRO-1,4-BENZOTHIAZEPIN-4(5H)-YL)METHYL)BENZOIC ACID, HEMIFUMARATE
- Type
- sys
- Preferred
- false
- Display name
- false
- Languages
- en
- References
- 5bfdcec6-7699-4a3b-bf7f-28ad9f6d965b, 8a69d8b5-b23b-4ed5-bd2d-53ef031ad145
- Uuid
- cbc1b138-b083-415e-b0b6-a74f7cade340
- Name
- ARM-210 HEMIFUMARATE
- StdName
- ARM-210 HEMIFUMARATE
- Type
- cd
- Preferred
- false
- Display name
- false
- Languages
- en
- References
- 5bfdcec6-7699-4a3b-bf7f-28ad9f6d965b, 8a69d8b5-b23b-4ed5-bd2d-53ef031ad145
- Uuid
- 7d3cb37b-96fe-498a-ae62-fbf17831f29d
- Name
- BENZOIC ACID, 4-((2,3-DIHYDRO-7-METHOXY-1,4-BENZOTHIAZEPIN-4(5H)-YL)METHYL)-, (2E)-2-BUTENEDIOATE (2:1)
- StdName
- BENZOIC ACID, 4-((2,3-DIHYDRO-7-METHOXY-1,4-BENZOTHIAZEPIN-4(5H)-YL)METHYL)-, (2E)-2-BUTENEDIOATE (2:1)
- Type
- sys
- Preferred
- false
- Display name
- false
- Languages
- en
- References
- 58519726-6073-4ebd-afcf-8c26ca24ddcd, 8a69d8b5-b23b-4ed5-bd2d-53ef031ad145
- Uuid
- a3b25ee0-f8e2-418b-932c-866e904977fd
- Name
- Surlorian hemifumarate
- StdName
- SURLORIAN HEMIFUMARATE
- Type
- cn
- Preferred
- false
- Display name
- true
- Languages
- en
- References
- d619e6f6-e7a5-4ec5-be28-13cba7e3e158
- References
- Uuid
- 5bfdcec6-7699-4a3b-bf7f-28ad9f6d965b
- Citation
- orphan drug
- Url
- https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=501515
- Doc type
- SRS
- Public domain
- true
- Tags
- NOMEN, PUBLIC_DOMAIN_RELEASE, AUTO_SELECTED
- Uuid
- 8a69d8b5-b23b-4ed5-bd2d-53ef031ad145
- Citation
- ORPHAN DRUG
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- ORPHAN DRUG
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- Tags
- NOMEN
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- Public domain
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- Tags
- NOMEN
- Uuid
- 7ac104c6-6ca3-4a5c-9a95-6f7e157a3b3f
- Citation
- SRS CODE IMPORT
- Doc type
- SRS
- Public domain
- true
- Document date
- 1493394095000
- Tags
- NOMEN
- Uuid
- 84180883-73b3-dbc2-78dc-9016f31541fc
- Citation
- PUBCHEM
- Doc type
- NLM
- Public domain
- true
- Tags
- PUBLIC_DOMAIN_RELEASE
- Uuid
- 57e9f12a-d403-6c8f-ab41-533ede864ab9
- Doc type
- SYSTEM
- Public domain
- true
- Uuid
- 88bbdd07-e102-44cd-a373-3548baaef518
- Citation
- STN
- Doc type
- STN (SCIFINDER)
- Public domain
- true
- Uuid
- d619e6f6-e7a5-4ec5-be28-13cba7e3e158
- Citation
- SRS
- Doc type
- SRS
- Public domain
- true
- Tags
- PUBLIC_DOMAIN_RELEASE
- Moieties
- Uuid
- 27f30f13-4e62-4784-9752-5c1c96bf5adf
- ID
- 27f30f13-4e62-4784-9752-5c1c96bf5adf
- Smiles
- C(=C\C(=O)O)/C(=O)O
- Formula
- C4H4O4
- Atropisomerism
- No
- Charge
- 0
- Count
- 1
- Stereochemistry
- ACHIRAL
- Defined stereo
- 0
- Ez centers
- 1
- Molecular weight
- 116.0723
- Optical activity
- NONE
- Stereo centers
- 0
- Molfile
Marvin 01132102112D 8 7 0 0 0 0 999 V2000 2.5974 -4.8237 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.3117 -4.4111 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3117 -3.5863 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.0261 -4.8237 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7406 -4.4111 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4549 -4.8237 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1694 -4.4111 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4549 -5.6486 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 4 5 2 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 M END
- Count amount
- Type
- MOL RATIO
- Average
- 1
- Units
- MOL RATIO
- Uuid
- f17cfe42-3b05-4fab-865f-e1252e938e91
- Uuid
- 66914698-8cc7-4da8-9173-eef507583597
- ID
- 66914698-8cc7-4da8-9173-eef507583597
- Smiles
- COc1ccc2c(c1)CN(CCS2)Cc3ccc(cc3)C(=O)O
- Formula
- C18H19NO3S
- Atropisomerism
- No
- Charge
- 0
- Count
- 2
- Stereochemistry
- ACHIRAL
- Defined stereo
- 0
- Ez centers
- 0
- Molecular weight
- 329.4151
- Optical activity
- NONE
- Stereo centers
- 0
- Molfile
Marvin 01132105202D 23 25 0 0 0 0 999 V2000 2.7754 -2.0576 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4914 -2.4702 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.2074 -2.0576 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2074 -1.2327 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9233 -0.8201 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6392 -1.2327 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2824 -0.7161 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 7.0892 -0.9018 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4456 -1.6451 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0892 -2.3885 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.6057 -3.0364 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4203 -2.9135 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9369 -3.5568 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7517 -3.4340 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0545 -2.6631 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5379 -2.0199 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7232 -2.1427 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8692 -2.5402 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1720 -1.7742 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.3858 -3.1882 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.2824 -2.5740 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6392 -2.0576 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9233 -2.4702 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 0 0 3 2 1 0 0 0 0 3 4 1 0 0 0 0 23 3 2 0 0 0 0 4 5 2 0 0 0 0 5 6 1 0 0 0 0 7 6 1 0 0 0 0 22 6 2 0 0 0 0 7 8 1 0 0 0 0 8 9 1 0 0 0 0 9 10 1 0 0 0 0 11 10 1 0 0 0 0 10 21 1 0 0 0 0 12 11 1 0 0 0 0 13 12 1 0 0 0 0 12 17 2 0 0 0 0 14 13 2 0 0 0 0 15 14 1 0 0 0 0 15 16 2 0 0 0 0 18 15 1 0 0 0 0 17 16 1 0 0 0 0 18 19 1 0 0 0 0 18 20 2 0 0 0 0 21 22 1 0 0 0 0 23 22 1 0 0 0 0 M END
- Count amount
- Type
- MOL RATIO
- Average
- 2
- Units
- MOL RATIO
- Uuid
- 15c38e53-7c68-4323-881c-d3ab2538d85a
- Structure
- ID
- a0f47bfe-2447-4b1e-9782-65f7fdf626f7
- Smiles
- COc1ccc2c(c1)CN(CCS2)Cc3ccc(cc3)C(=O)O.COc1ccc2c(c1)CN(CCS2)Cc3ccc(cc3)C(=O)O.C(=C\C(=O)O)/C(=O)O
- Formula
- 2C18H19NO3S.C4H4O4
- Atropisomerism
- No
- Charge
- 0
- Count
- 1
- Stereochemistry
- ACHIRAL
- Defined stereo
- 0
- Ez centers
- 1
- Molecular weight
- 774.9026
- Optical activity
- NONE
- Stereo centers
- 0
- Molfile
Marvin 01132108222D 54 57 0 0 0 0 999 V2000 17.5762 -8.7576 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 18.7139 -8.1007 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8516 -8.7576 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.9893 -8.1007 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1271 -8.7576 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.2649 -8.1007 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 22.1271 -10.0714 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 18.7139 -6.7870 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 24.3088 -3.6159 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.4940 -3.7388 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1912 -4.5097 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.3765 -4.6324 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.8599 -3.9892 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1628 -3.2183 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.9775 -3.0955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.0453 -4.1121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5288 -3.4642 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 20.8852 -2.7208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5288 -1.9775 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.7221 -1.7918 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 19.0788 -2.3084 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0788 -3.1333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.7221 -3.6497 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3630 -3.5458 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6471 -3.1333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6471 -2.3084 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3630 -1.8958 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9311 -3.5458 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 16.2151 -3.1333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 24.6116 -2.8498 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 24.8254 -4.2638 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 24.3088 -3.6159 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.4940 -3.7388 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1912 -4.5097 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.3765 -4.6324 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.8599 -3.9892 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1628 -3.2183 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 22.9775 -3.0955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 21.0453 -4.1121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5288 -3.4642 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 20.8852 -2.7208 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5288 -1.9775 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.7221 -1.7918 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 19.0788 -2.3084 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0788 -3.1333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 19.7221 -3.6497 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3630 -3.5458 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6471 -3.1333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6471 -2.3084 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3630 -1.8958 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9311 -3.5458 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 16.2151 -3.1333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 24.6116 -2.8498 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 24.8254 -4.2638 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 24 22 2 0 0 0 0 24 25 1 0 0 0 0 25 26 2 0 0 0 0 26 27 1 0 0 0 0 27 21 2 0 0 0 0 25 28 1 0 0 0 0 28 29 1 0 0 0 0 9 30 2 0 0 0 0 9 31 1 0 0 0 0 2 3 1 0 0 0 0 3 4 2 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 7 2 0 0 0 0 2 8 2 0 0 0 0 1 2 1 0 0 0 0 9 10 1 0 0 0 0 10 11 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 13 14 2 0 0 0 0 14 15 1 0 0 0 0 10 15 2 0 0 0 0 13 16 1 0 0 0 0 16 17 1 0 0 0 0 18 17 1 0 0 0 0 19 18 1 0 0 0 0 20 19 1 0 0 0 0 20 21 1 0 0 0 0 22 21 1 0 0 0 0 23 22 1 0 0 0 0 17 23 1 0 0 0 0 32 53 2 0 0 0 0 32 54 1 0 0 0 0 32 33 1 0 0 0 0 33 34 1 0 0 0 0 33 38 2 0 0 0 0 34 35 2 0 0 0 0 35 36 1 0 0 0 0 36 37 2 0 0 0 0 36 39 1 0 0 0 0 37 38 1 0 0 0 0 39 40 1 0 0 0 0 41 40 1 0 0 0 0 40 46 1 0 0 0 0 42 41 1 0 0 0 0 43 42 1 0 0 0 0 43 44 1 0 0 0 0 50 44 2 0 0 0 0 45 44 1 0 0 0 0 47 45 2 0 0 0 0 46 45 1 0 0 0 0 47 48 1 0 0 0 0 48 49 2 0 0 0 0 48 51 1 0 0 0 0 49 50 1 0 0 0 0 51 52 1 0 0 0 0 M STY 1 1 MUL M SAL 1 15 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 M SAL 1 15 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 M SAL 1 15 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 M SAL 1 1 54 M SPA 1 15 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 M SPA 1 8 24 25 26 27 28 29 30 31 M SDI 1 4 15.7951 -5.0524 15.7951 -1.3718 M SDI 1 4 25.2454 -1.3718 25.2454 -5.0524 M SMT 1 2 M END
- References
- 5bfdcec6-7699-4a3b-bf7f-28ad9f6d965b