Substances (GSRS)

1-((P-CHLOROPHENOXY)METHYL)-1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL

Also: 6,7-ISOQUINOLINEDIOL, 1-((4-CHLOROPHENOXY)METHYL)-1,2,3,4-TETRAHYDRO-, CLOFEVERINE, CLOFEVERINE [JAN] +1

chemicalUNII 584A0O55XM
Open FDA's page for this record
Substance class
chemical
Definition type
PRIMARY
Definition level
COMPLETE
Uuid
54ef203f-2a3a-4822-9f26-8d94db0abdab
Version
11
UNII
584A0O55XM
Codes
  1. Uuid
    c1eadfcf-c414-4464-a456-3e6d3c76f6b0
    Code
    54340-63-5
    Type
    PRIMARY
    Url
    https://commonchemistry.cas.org/detail?cas_rn=54340-63-5
    Code system
    CAS
    References
    1e17b364-75be-425f-951e-3ff7e91cc047, 90ae7497-b79c-42fd-8633-9086bc8fd65a
  2. Uuid
    2d3120aa-5112-49cd-8fbf-363ef53bcedc
    Code
    C77986
    Type
    PRIMARY
    Url
    https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C77986
    Code system
    NCI_THESAURUS
    References
    1e17b364-75be-425f-951e-3ff7e91cc047
  3. Uuid
    ff58584c-e723-42c3-8a47-6c299b66489d
    Code
    SUB06703MIG
    Type
    PRIMARY
    Code system
    EVMPD
    References
    1e17b364-75be-425f-951e-3ff7e91cc047
  4. Uuid
    71e3c5df-1621-4ebc-aec3-7c78ed8c58b4
    Code
    3531
    Type
    PRIMARY
    Url
    https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=3531
    Code system
    INN
    References
    1e17b364-75be-425f-951e-3ff7e91cc047
  5. Uuid
    87e7473f-b2f3-421c-aba8-3b4e13b8b8b0
    Code
    CHEMBL2106010
    Type
    PRIMARY
    Url
    https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2106010
    Code system
    ChEMBL
    References
    1e17b364-75be-425f-951e-3ff7e91cc047
  6. Uuid
    9e35cbf2-0ff2-4fbc-9b8e-aaac111f061e
    Code
    194700
    Type
    PRIMARY
    Url
    https://pubchem.ncbi.nlm.nih.gov/compound/194700
    Code system
    PUBCHEM
    References
    1e17b364-75be-425f-951e-3ff7e91cc047
  7. Uuid
    ffc32d30-1969-dfe2-6d4a-51e6ed4578e5
    Code
    C66880
    Comments
    Pharmacologic Substance[C1909]|Agent Affecting Nervous System[C78272]|Anticholinergic Agent
    Type
    CONCEPT
    Url
    https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66880
    Code system
    NCI_THESAURUS
    References
    4121a252-6f67-f8ff-7a55-598133283121
  8. Uuid
    1ca7b8e7-1363-4d7d-9107-201b227fe51b
    Code
    584A0O55XM
    Type
    PRIMARY
    Code system
    FDA UNII
  9. Uuid
    397c0781-cd0d-c1a8-4664-94d8894ead27
    Code
    100000084313
    Type
    PRIMARY
    Code system
    SMS_ID
    References
    63b4c4e4-bb6b-2fc8-9f62-2ab6318634a5
  10. Uuid
    aea37a34-908a-90e8-164c-6abd85881bc5
    Code
    DTXSID70969433
    Type
    PRIMARY
    Url
    https://comptox.epa.gov/dashboard/chemical/details/DTXSID70969433
    Code system
    EPA CompTox
    References
    7cc29a09-3488-0ee2-03d9-61ade73b4c95
Relationships
  1. Uuid
    7a05503a-79b2-47a5-9946-117db72613fc
    Type
    ACTIVE MOIETY
    Related substance
    Uuid
    c597f906-4cf9-443f-bb63-097ee5835e09
    Refuuid
    54ef203f-2a3a-4822-9f26-8d94db0abdab
    Name
    CLOFEVERINE
    UNII
    584A0O55XM
    Linking ID
    584A0O55XM
    Ref pname
    CLOFEVERINE
    Substance class
    reference
  2. Uuid
    9eeb1b85-c408-4b5d-96f6-a8678115fc65
    Type
    ENANTIOMER->RACEMATE
    Related substance
    Uuid
    03c67f7e-8149-4be0-ae69-c3d3c29bf6f8
    Refuuid
    2f703443-de60-4fa9-8404-ecaed941feda
    Name
    CLOFEVERINE, (R)-
    UNII
    7LW9H54P1D
    Linking ID
    7LW9H54P1D
    Ref pname
    CLOFEVERINE, (R)-
    Substance class
    reference
  3. Uuid
    aaf54b3d-50b2-40ec-bd0e-01c9c181c587
    Type
    ENANTIOMER->RACEMATE
    Related substance
    Uuid
    9472de2e-22ab-481a-aff2-5169060c3db6
    Refuuid
    8ab1164f-3ddf-43b5-92b8-1a382b790266
    Name
    CLOFEVERINE, (S)-
    UNII
    9PR0NPE89W
    Linking ID
    9PR0NPE89W
    Ref pname
    CLOFEVERINE, (S)-
    Substance class
    reference
  4. Uuid
    ffa6da7c-874c-4ef8-9c46-8f4abb1cf7a7
    Type
    SALT/SOLVATE->PARENT
    Related substance
    Uuid
    fd0a4a36-8d9d-4c42-b381-9fe70b03bc23
    Refuuid
    473a4db6-86e2-4ece-9f79-8cbc22c5ee02
    Name
    CLOFEVERINE HYDROCHLORIDE
    UNII
    32FN39XWR3
    Linking ID
    32FN39XWR3
    Ref pname
    CLOFEVERINE HYDROCHLORIDE
    Substance class
    reference
Names
  1. Uuid
    45dbdd1b-979c-468b-b79b-b4e758a4d4c4
    Name
    1-((P-CHLOROPHENOXY)METHYL)-1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL
    StdName
    1-((P-CHLOROPHENOXY)METHYL)-1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    e45654b8-eaa8-499f-aa12-7ae8e4aa8436
  2. Uuid
    ba3db26e-ab4d-41ee-bd71-af6a22fd58ad
    Name
    6,7-ISOQUINOLINEDIOL, 1-((4-CHLOROPHENOXY)METHYL)-1,2,3,4-TETRAHYDRO-
    StdName
    6,7-ISOQUINOLINEDIOL, 1-((4-CHLOROPHENOXY)METHYL)-1,2,3,4-TETRAHYDRO-
    Type
    sys
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    7faf3f60-f9aa-4d5d-8137-459e6d7a9a86, 84137d3b-b5a8-4e48-9002-fd1c14ce4379
  3. Uuid
    f9bb5200-31c5-4961-b6f0-22b014814c1b
    Name
    CLOFEVERINE
    StdName
    CLOFEVERINE
    Type
    of
    Preferred
    false
    Display name
    true
    Languages
    en
    References
    e45654b8-eaa8-499f-aa12-7ae8e4aa8436, c6ed048a-9d65-48be-bb16-de5a3db908bc, 33fbd7cf-b082-43fc-9ada-2d1483d96be3
    Domains
    drug
    Name orgs
    1. Uuid
      fa868e20-38a6-4971-a1ca-1367e4edb75b
      Name org
      INN
  4. Uuid
    8524b5b9-8a86-4ede-9d44-47364c8a962e
    Name
    CLOFEVERINE [JAN]
    StdName
    CLOFEVERINE [JAN]
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    1ebb1568-55c4-c7fa-ca2b-5f706b7582fa
  5. Uuid
    7fe075c9-9e33-41ff-baee-0a10e8f113c1
    Name
    clofeverine [INN]
    StdName
    CLOFEVERINE [INN]
    Type
    cn
    Preferred
    false
    Display name
    false
    Languages
    en
    References
    c6ed048a-9d65-48be-bb16-de5a3db908bc
References
  1. Uuid
    e45654b8-eaa8-499f-aa12-7ae8e4aa8436
    Citation
    USP DICTIONARY 2008
    Doc type
    SRS
    Public domain
    true
    Tags
    NOMEN, PUBLIC_DOMAIN_RELEASE, AUTO_SELECTED
  2. Uuid
    7faf3f60-f9aa-4d5d-8137-459e6d7a9a86
    Citation
    STN
    Doc type
    SRS
    Public domain
    true
    Tags
    NOMEN
  3. Uuid
    84137d3b-b5a8-4e48-9002-fd1c14ce4379
    Citation
    STN (SCIFINDER)
    Doc type
    STN (SCIFINDER)
    Public domain
    true
    Tags
    NOMEN
  4. Uuid
    c6ed048a-9d65-48be-bb16-de5a3db908bc
    Citation
    INN Proposed List 31
    Url
    https://www.who.int/medicines/publications/druginformation/innlists/PL31.pdf
    Doc type
    INN_LIST
    Public domain
    true
    Tags
    PUBLIC_DOMAIN_RELEASE
  5. Uuid
    1e17b364-75be-425f-951e-3ff7e91cc047
    Citation
    SRS CODE IMPORT
    Doc type
    SRS
    Public domain
    true
    Document date
    1493390709000
    Tags
    NOMEN
  6. Uuid
    a08f47b5-605b-4eec-bff6-6515258d2679
    Citation
    SRS import [584A0O55XM]
    Url
    http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=584A0O55XM
    Doc type
    SRS
    Public domain
    true
    Document date
    1493390709000
    Tags
    NOMEN
  7. Uuid
    33fbd7cf-b082-43fc-9ada-2d1483d96be3
    Citation
    CLOFEVERINE [INN]
    Doc type
    SRS_LOCATOR
    Public domain
    true
  8. Uuid
    1ebb1568-55c4-c7fa-ca2b-5f706b7582fa
    Citation
    JAN
    Doc type
    SRS
    Public domain
    true
    Tags
    NOMEN, PUBLIC_DOMAIN_RELEASE
  9. Uuid
    63b4c4e4-bb6b-2fc8-9f62-2ab6318634a5
    Citation
    EU-SRS
    Doc type
    EMA LIST
    Public domain
    true
  10. Uuid
    4121a252-6f67-f8ff-7a55-598133283121
    Doc type
    SYSTEM
    Public domain
    true
  11. Uuid
    90ae7497-b79c-42fd-8633-9086bc8fd65a
    Citation
    STN
    Doc type
    STN (SCIFINDER)
    Public domain
    true
  12. Uuid
    7cc29a09-3488-0ee2-03d9-61ade73b4c95
    Citation
    EPA CompTox
    Doc type
    EPA
    Public domain
    true
Moieties
  1. Uuid
    5f96c0bf-a20c-4772-a497-0b81b58c2c55
    ID
    5f96c0bf-a20c-4772-a497-0b81b58c2c55
    Smiles
    c1cc(ccc1Cl)OCC2c3cc(c(cc3CCN2)O)O
    Formula
    C16H16ClNO3
    Atropisomerism
    No
    Charge
    0
    Count
    1
    Stereochemistry
    RACEMIC
    Defined stereo
    0
    Ez centers
    0
    Molecular weight
    305.7567
    Optical activity
    ( + / - )
    Stereo centers
    1
    Molfile

    Marvin 01132104572D 21 23 0 0 0 0 999 V2000 -0.1213 -0.7370 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.5931 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5931 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 -2.3870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 -3.2120 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0221 -3.6245 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7366 -3.2120 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7366 -2.3870 0.0000 C 0 0 0 0 0 0 0 0 0 3 0 0 3.4511 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1655 -2.3870 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.8800 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8800 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5945 -0.7370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3089 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0234 -0.7370 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3089 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5945 -2.3870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0221 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0221 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 -0.7370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 0.0880 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 0 0 3 2 1 0 0 0 0 2 20 2 0 0 0 0 4 3 2 0 0 0 0 5 4 1 0 0 0 0 4 18 1 0 0 0 0 6 5 1 0 0 0 0 7 6 1 0 0 0 0 8 7 1 0 0 0 0 8 9 1 0 0 0 0 8 18 1 0 0 0 0 9 10 1 0 0 0 0 10 11 1 0 0 0 0 11 12 1 0 0 0 0 11 17 2 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 14 15 1 0 0 0 0 14 16 2 0 0 0 0 16 17 1 0 0 0 0 19 18 2 0 0 0 0 20 19 1 0 0 0 0 20 21 1 0 0 0 0 M END

    Count amount
    Type
    MOL RATIO
    Average
    1
    Units
    MOL RATIO
    Uuid
    13e26cfa-0617-4d58-9fa3-f91d436bef62
Structure
ID
999f50dc-27d5-4c8e-98c6-60ad824b659a
Smiles
c1cc(ccc1Cl)OCC2c3cc(c(cc3CCN2)O)O
Formula
C16H16ClNO3
Atropisomerism
No
Charge
0
Count
1
Stereochemistry
RACEMIC
Defined stereo
0
Ez centers
0
Molecular weight
305.7567
Optical activity
( + / - )
Stereo centers
1
Molfile

Marvin 01132107592D 21 23 0 0 0 0 999 V2000 2.7366 -2.3870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7366 -3.2120 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.0221 -3.6245 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 -3.2120 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 -2.3870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5931 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5931 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 -0.7370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0221 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0221 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.1213 -0.7370 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3077 0.0880 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4511 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1655 -2.3870 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.8800 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8800 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5945 -0.7370 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3089 -1.1495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3089 -1.9745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5945 -2.3870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0234 -0.7370 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 2 3 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 6 7 2 0 0 0 0 7 8 1 0 0 0 0 8 9 2 0 0 0 0 9 10 1 0 0 0 0 1 10 1 0 0 0 0 5 10 2 0 0 0 0 7 11 1 0 0 0 0 8 12 1 0 0 0 0 15 16 1 0 0 0 0 16 17 2 0 0 0 0 17 18 1 0 0 0 0 18 19 2 0 0 0 0 19 20 1 0 0 0 0 15 20 2 0 0 0 0 14 15 1 0 0 0 0 18 21 1 0 0 0 0 13 14 1 0 0 0 0 1 13 1 0 0 0 0 M END

References
e45654b8-eaa8-499f-aa12-7ae8e4aa8436, a08f47b5-605b-4eec-bff6-6515258d2679, c6ed048a-9d65-48be-bb16-de5a3db908bc
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Data from openFDA, FDA's public API. FDA says not to rely on it to make decisions about medical care and to treat every result as unvalidated; confirm against FDA's own record and the product labeling. Not medical or legal advice.